The effect of subchronic supplementation with folic acid on homocysteine induced seizures

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the effect of subchronic supplementation with folic acid on homocysteine induced seizures

influence of folic acid on the cns is still unclear. folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. the aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (eeg) characteristics of dl homocysteine thiolactone induced seizures in adult rats. t...

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The effect of subchronic supplementation with folic acid on homocysteine induced seizures.

Influence of folic acid on the CNS is still unclear. Folate has a neuroprotective effect, while on the other hand excess folate can exacerbate seizures in epileptics. The aim of the present study was to examine the effect of subchronic administration of folic acid on behavioural and electroencephalographic (EEG) characteristics of DL homocysteine thiolactone induced seizures in adult rats. The ...

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In trophoblast cells exposed to homocysteine (Hcy) we observed cellular apoptosis and the inhibition of trophoblast functions. Because folate and Hcy, linked in the same metabolic pathway, are inversely related, we investigated the role of folic acid in reversing the Hcy effect in human placenta. In primary trophoblast cells we examined the cytosolic release of cytochrome c, both M30 and termin...

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ژورنال

عنوان ژورنال: Acta Physiologica Hungarica

سال: 2015

ISSN: 0231-424X,1588-2683

DOI: 10.1556/036.102.2015.2.6